Από το εγκυρότατο soundonsound.com
There are several differences between Rewire and VST 2.0 Instruments. The main one is that Rewire applications can also run in stand-alone mode, whereas VST instruments are always launched and run from within Cubase VST. The user interface of the VST Instrument is a single window, just like that of any other plug-in, but the user Interface of a Rewire-compatible product can be anything the developer desires. The latency of VST 2.0 Instruments is exactly that of the soundcard when used for normal audio work. If you have one with low-latency ASIO drivers then you'll be pleased; if not then real-time performances will probably be out. Mind you, ASIO latency values seem to be dropping rapidly in all the cards released recently, which should benefit both VST Instruments and Rewire applications.